Preimplantation Genetic Testing for Monogenic Disorders (PGT-M) using Comprehensive Chromosome Screening (CCS) can help identify which embryos produced during an IVF treatment cycle are capable of developing into a viable pregnancy.
Embryos with a higher likelihood of producing a successful pregnancy are distinguished from those with lower potential by examining the chromosomes in a small number of cells (or a single cell) carefully sampled from the embryo. Chromosomally normal embryos are more likely to implant, and pregnancies resulting from them have a reduced risk of miscarriage.
Comprehensive chromosome analysis is performed in our laboratory using a technology called microarray comparative genomic hybridization (array-CGH or aCGH). aCGH examines every chromosome in the embryo, including sex chromosomes. This makes aCGH different from previous PGT-M tests, which could only examine a limited number of chromosomes. Additionally, Reprogenetics Middle East now offers Next Generation Sequencing (NGS) for CCS. Please contact us for more information about our NGS service.
By combining CCS with routine embryological microscopic examinations, we maximize the chances of pregnancy, reduce the risk of miscarriage, and increase the likelihood of a successful delivery.
The procedure begins with an embryo biopsy, which involves the microsurgical removal of a few cells from a day 5 embryo (blastocyst stage). Alternatively, a single cell can be taken on day 3 of embryonic development (cleavage stage).
The biopsied cells are placed in special containers and sent to the Reprogenetics laboratory for analysis via aCGH. Results are provided to the referring IVF center within 24 hours of receiving the samples.
The embryos remain at the IVF clinic and are returned to the incubator until the test results are available.
- Simultaneously analyzes multiple locations across the entire length of each chromosome.
- Detects aneuploidies in any of the 24 chromosomes in human embryos, including rare chromosomal abnormalities.
- Does not require additional blood tests prior to the IVF cycle.